ColActive® Plus and ColActive® Plus Ag are collagen dressings made from a patented blend of collagen,
EDTA (ethylenediaminetetracetic acid), alginate and CMC (carboxymethylcellulose).
This unique formulation:
• lowers select excess MMP activity better than the leading competitive collagen dressing1, 2
• maintains wound pH levels that do not harm growth factors, plasma proteins and other cell types that are required for wound healing3
• contains EDTA, which has shown to be a potent inhibitor of biofilm formation and disruptor of mature biofilms4
• is a fish-derived collagen source, making it acceptable for many cultures and religions
ColActive® Plus Ag provides additional benefits of 5% ionic silver in the formulation, providing broad spectrum antimicrobial activity.
How does it work?
ColActive® Plus and ColActive® Plus Ag are Collagen dressings that act as a sacrificial substrate that attracts harmful excess MMP’s from the wound.
• EDTA is a metal-chelator that deactivates MMPs by binding with zinc ions and has also shown to be a potent inhibitor of biofilm formation and disruptor of mature biofilms.4
• Alginate and CMC work together to optimally maintain a moist wound environment that allows the product to transform to a soft gel, absorbing up to 20 times its weight in wound drainage.
• ColActive® Plus Ag’s 5% ionic silver acts as a potent antimicrobial agent.
Recent clinical studies found:
• 88% of ColActive® Plus Ag patients showed significant chronic wound healing over an 8-week time period, with an average wound size reduction of 65%.5
• Second-degree burns treated with ColActive® Plus Ag experienced a faster speed of epithelialization than those treated with the institution’s traditional standard of care.6
1 Covalon Technologies Ltd. Data on file. 2 Covalon Technologies Ltd. Data on file. 3 Lewis, K.M. et al. Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents. Eur. Surg. 45, 213-220 2013. 4 Finnegan, S. and Percival, S. EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care. Adv Wound Care (New Rochelle). 4(7): 415-421. Jul 1 2015. 5 Alavi, A. M.D. F.R.C.P.C. et al. A Case Series to Evaluate the Clinical Effectiveness of a Collagen Matrix Wound Dressing. Presented at The Symposium on Advanced Wound Care (SAWC) April 5-9, 2017, San Diego, CA, USA. 6 Salehi, H. et al. Comparing The Effect of ColActive Plus Ag Dressing versus Nitrofurazone and Vaseline Gauze Dressing in the Treatment of Second-Degree Burns. Annals of Burns and Fire Disasters. Vol XXXI. n3. September 2018.